PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITIONS OF ANTITUMOR ACTIVITY CONTAINING COMPLEXES OF THE METALS OF THE (VIII) GROUP AND PHARMACEUTICALLY ACTIVE PHOSPHINO-HYDROCARBON GROUPS

摘要

Novel bis[bis(diphenylphosphino)hydrocarbon] and bis[diphenylphosphino-diphenylarsino)hydrocarbon]-group VIII metal compounds of the formula 1 of the formula sheet, wherein D1=D2=phosphorus or D1=phosphorus and D2=arsenic; A=(CH2)2 or cis-CH=CH; X1=X2 (both if present)=halo or nitrato or X1+X=peroxo; Y (if present)=halide, nitrate, perchlorate, triflate or tetrahaloferrate (III) p1 n=0, 1 or 2; M=Fe(II) Fe(III), Co(II) Rh(I) , Rh(III), Ir(I), Ir(III), Ni(II) or Pd(II), showing a tumor cell growth-inhibiting activity, novel pharmaceutical compositions containing said compounds and a method for treating tumor cells, sensitive to said compounds.