Synthesis of Carboxybenzyl-Protected 2′-Deoxynucleoside 5′- Phosphoromorpholidates

摘要

Four deoxynucleoside 5′-phosphoromorpholidates were prepared from carboxybenzylprotected 2′-deoxyribonucleosides. The synthetic route involved three consecutive steps including phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling- reactions.