Design and Electromagnetic FEM Analysis of a High Gradient Magnet for the Magnetic Targeted Drug Delivery System

摘要

Magnetic targeted-drug delivery system (MTDs) works as a promising cancer treatment approach, and is entering the mainstream. It applies an external magnetic field to attract and guide the magnetic nanoparticles (MNPs) carrying treatment agent and targeted antibodies to the lesion region. Its key factor is the high gradient magnet. Here three types of magnets are proposed, i.e., open circuit magnet, close circuit magnet with planar poles, and close circuit magnet with concave-convex poles. And then their magnet field distributions are calculated through the finite element method (FEM). The simulation results are compared with each other and the measurement of Gauss Meter for the manufactured magnet, and the primary experimental result is also reported. It is found the closed magnet circuit with concave-convex poles shows about 2.0 and 1.2 times higher magnetic field intensity (H) than the open magnet circuit and the close magnet circuit with planar poles, respectively. Most important is it owns largest Grad(H) (1.0 e6 A/m~2) among three magnets. The simulation agrees well with the measurement, and the primary experimental results also show the magnet can attract MNPs efficiently. Hence the calculation enables provide with credible input for the further trajectory simulation for MNPs.