Stereospecifc interligand interactions afecting base-specifc and high-order structure-specifc metal bonding to nucleic acid constituents and polynucleotides

摘要

We have demonstrated the importance of stereospecifc interligand interactions as a factor that could affect base- and site-specifc metal bonding to nucleic acid constituents, based on X-ray studies of the rationally designed metal complexes that could specifcally recognize adenine or guanine bases among the fve common bases. High-order structure-specifc metal bonding to polynucleotides is also briefy discussed in terms of stereospecifc interligand interactions.