The Roles of First and Second Coordination Environments in the Active Metal Center of NiSOD

摘要

To elucidate the relationship between structure and function in NiSOD active center, we prepared three Ni(II) complexes with an N2S2-type square planar structure, 1, 2, and 3, as its model compounds. They were characterized structurally, spectro-scopically and electrochemically. From the comparison of redox potentials of these complexes in several solvents, we have proposed that the amino-amidato-dithiolato type N2S2-donor set in the first coordination sphere and the H-bonding interactions in the second coordination sphere significantly contribute to SOD function.