In vivo monitoring of Organ-Selective distribution ofCdHgTe/SiO_2 Nanoparticles in mouse model

摘要

CdHgTe/SiO_2 nanoparticles were prepared by SiO_2 capping on the surface of CdHgTe quantum dots (QDs). The characteristics, such as optical spectra, size and optical stability were investigated. The size of CdHgTe/SiO_2 nanoparticles could be larger than 100 nm after CdHgTe QDs capped with SiO_2. CdHgTe/SiO_2 nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 790 nm and a full width at half-maximum (FWHM) of 50-70 nm. The in vivo fluorescence imaging of CdHgTe/SiO_2 nanoparticles in mouse model indicated the nanoparticles could be passively targeting to lung and liver. CdHgTe/SiO_2 nanoparticles offer new perspectives for size dependent bio-dstribution studies in living body.