14-3-3 sigma null mouse, development of in vivo septic shock research model using the same and use of the same

摘要

The purpose of the present invention is developing an in vivo sepsis researching model. The present invention relates to a 14-3-3 sigma gene-lacking mouse, to a method for developing an in vivo sepsis research model using the same, and to a use of the same. Moreover, the method in the present invention comprises the steps of: treating a transgenic mouse lack of a 14-3-3 sigma gene with a test material; and measuring the survival rate of the transgenic mouse in the presence of the test material, wherein the 14-3-3 sigma gene is preferred to have a base sequence of the sequence number 1, but all the mutant genes having one or more of substitution, deletion, inversion, and/or translocation mutation on the gene are included in the range of the present invention.