The transition from hadron phase to strange quark phase in dense matter is investigated. Instead of using the conventional bag model in quark sect, we achieve the confinement by a density-dependent quark mass derived from in-medium chiral condensates, with a thermodynamic problem improved. In nuclear slot, we adopt the equation of state from Brueckner-Bethe-Goldstone approach with three-body force. It is found that the mixed phase can occur, for reasonable confinement parameter, near the normal saturation density, and transit to pure quark matter at 4-5 times the saturation, which is quite different from the previous results from other quark models that pure quark phase can not appear at neutron-star densities.
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