Mechanical properties of compacts made with binary mixtures of pharmaceutical excipients of three different kinds

摘要

Three pharmaceutical excipients and their binary mixtures were compacted to form compacts of various mean porosities. The mechanical properties (Young's modulus, tensile strength and Brinell hardness) of the binary mixtures were not proportional to the mixture composition expressed in mass. More, for all the properties, a negative deviation was always observed from this linear relationship. Secondly, a predictive model based on a statistical approach was proposed for the Young's modulus and the tensile strength. Finally, the X-ray tomography technique allowed explaining the non linear relationship of the different mechanical properties results observed on these binary mixtures.