Solid Phase Synthesis of Cyclic Peptides with a Guanidine Bridge

摘要

Cyclisation through covalent linkage between two side-chains has often proved to be efficient in producing peptide analogues with improved biological properties, i.e. metabolic stability, potency, and target selectivity. Cyclisation can be achieved by the formation of a disulfide bond, an amide bond, ring closing metathesis…^