Immune Cell Transplantation: New Perspectives in the Correction of Morphine - Induced Immune and Behavior Disorders

摘要

Introduction In our studies we've shown that mice with different levels of exploratory behavior (EB) differed also in immune status [1-3]; and behavioral characteristic could be regulated by the transplantation of the immune cells. Splenocytes from (CBAxC-57BL/6) F1 mice-donors with definite characteristics of the behavior in "open field" test, directionally change behavior in syngeneic mice-recipients after intravenous administration [1]. Opiates are known to affect both immune response and behavior. We studied behavior and immune changes in morphine dependent mice with different levels of EB and analyzed the possibility of their correction by transplantation of immune cells from healthy donors.