Comparison of cellular immune recovery toward CMV and adenovirus (AdV) between related and unrelated pediatric hematopoietic-stem cell transplantation

摘要

Adenovirus (AdV) and cytomegalovims (CMV) are significant causes of morbidity and mortality within the first 3 months following hematopoietic-stem cell transplantation (HSCT) because of incomplete T-cell immune recovery. Unrelated HSCT constitutes a major risk factor for severe infections in adults. It appears however less in children. Here, to evaluate the risk, we quantified AdV and CMV specific immune recovery in 28 pediatric recipients related to the status of the transplantation: 14 HLA-matched related donor (RD) and 14 unrelated donors (UD). Lower incidence of AdV and CMV-specific IFNgamma-secreting CD4 T-cells in UD at Ml contrasted with similar incidence and even higher level intensities at M3 post-HSCT in UD. Finally, lower incidence of positive proliferative responses were also observed at Ml and M3 in UD In conclusion, delayed rather than decreased CMV or AdV specific cellular immune recovery likely develop in unrelated pediatric transplantations.