In Vivo Evaluation of Ibuprofen-Loaded Poly(lactic-co-glycolic) Acid Nanoparticles in Rats

摘要

The aim of our studies was to formulate a nanoparticulate system that delivers the required dose of ibuprofen to the blood serum. The poly (lactic-co-glycolic acid, 50:50) nanoparticles were fabricated using emulsion solvent evaporation technique for the encapsulation of Ibuprofen. After oral administration of Ibuprofen-loaded nanoparticles in rats, drug concentration in blood serum was detected using HPLC. Drug loading and drug entrapment efficiency was detected with different drug loading. The results indicated that drug loading and drug entrapment were increased with increasing drug/PLGA ratio. The concentration profiles of ibuprofen released from nanoparticles indicated that the burst effect was reduced with a sustain drug release after administration. SEM images show the spherical shape and smooth surface of nanoparticles, with low PDI. In conclusion, our studies showed the significant increases in release time of optimum drug loading with a sustain drug release using ibuprofen/PLGA nanoparticles.