Experimental Design Aspects for Pharmaceutical Formulations

摘要

In pharmaceutical industries, formulators are often faced with the optimization of the mixture composition of nanoparticles aimed to prepare a product with the required characteristics by the FDA. The majority of existing process models in the pharmaceutical manufacturing literature employs standard design of experiment and ignores the special nature of pharmaceutical formulations. The primary purpose of this paper is twofold. First, this paper considers the dependency of the ingredients of a pharmaceutical formulation. This paper then demonstrates how to find compromise parameter solutions in terms of the composition of particles. A numerical example is given to illustrate the analysis of nanoparticle pharmaceutical formulations.