The Kinetics Studies of Peroxynitrite Decomposition Catalyzed by 5, 10, 15, 20 - Tetrakis 4-(3-Piridiniumproxy) Phenyl-Porphyrin Cobalt(II)

摘要

Peroxynitrite is a toxic biological oxidant which has been implicated in many pathophysiological conditions. Metalloporphyrins can catalyze it decomposition to protect the cells. A cobalt water-soluble porphyrin Co(II)TPP-OC{sub}3Py was synthesized and its ability to catalyze peroxynitrite decomposition was studied by stopped-flow spectrophotometer. The catalytic activity of Co(II)T-PPOC{sub}3Py is comparable to iron and manganese porphyrins which have been investigated before. The catalytic mechanism is related to the intermediate formed from the reaction of Co(II)TPPOC{sub}3Py and peroxynitrite, and the catalytic ability depends on whether the intermediate is reduced easily.