Inhibitory Effects of 7-Carboxymethyloxy-3', 4', 5-Trimethoxy Flavone (DA-6034) on Helicobacter pylori-Induced NF-κB Activation and iNOS Expression in AGS Cells

摘要

The Helicobacter pylori were identified by Marshall and War ren in 1984. H. pylori survive in the forbidding harsh acid environment of the stomach and duodenum by hiding in the mucus layer and neutral izing gastric acid In its local surrounding environment. Multiple lines of evidence suggest that H. pylori infection is one of the primary causes of gastritis and peptic ulcer, which are provoked by oxidative stress and in flammation. More than 50% of the world's population is infected by this bacterium. The H. pylori-induced inflammation has been impli cated in the pathogenesis and progression of gastric cancer. DA-6034 (7-carboxymethyloxy-3',4',5-trimethoxy flavone) is a synthetic flavonoid known to possess anti-inflammatory activity. It has been reported that oral administration of DA-6034 suppresses the inflammatory bowel dis ease (IBD) in animal models. In this article, we attempted to examine the effect of DA-6034 on H. pylori-induced inflammation in human gastric cancer (AGS) cells by targeting NF-κB and extracellular signal-regulated kinase (ERK), a representative MAPK.