Rigid Model Membranes with pH-Sensitive 'Raft-switches': Applications in Liposome-mediated Drug Delivery for Cancer Therapy

摘要

pH-sensitive liposomes have been extensively studied to increase drug bioavailability within targeted cancer-cells, but they do not behave ideally in vivo. We use 'raft-switches' to develop pH-sensitive liposomes that retain their long circulation times, and preserve their pH-sensitivity in the presence of serum proteins.