Effects of formulation and technology on release profile of Ornidazole biodegradable gel

摘要

OBJECTIVE To study the effects of formulation and technology factors on drug release profile of Ornidazole biodegradable gel. METHODS Poly (lactic-co-glycolic acid) (PLGA) was used to fabricate the gel. HPLC was used to determine drug content in the gel and UV detection was used to determine in vitro release rate. Effects of type of PLGA and solvent, the weight ratio of PLGA to solvent, the ratio of drug to PLGA were studied. RESULTS The optimum formulation consisted of 49% PLGA (50:50 15000), 49% N-ethyl-2-pyrrolidone and 2% Ornidazole. The gel could sustain release for 7 days, the release profile during 0~5 day was conformed to zero-order kinetics (R2=0.9943). CONCLUSION The gel showed a good controlled release characteristics. The process and the formulation of oridazole gel was simple and available.