Studies on preparation and quality control of Compound hyperostosis cataplasm

摘要

Objective: To prepare the compound hyperostosiscataplasm and study its in vitro release characteristics and quality control. Methods: The compound hyperostosiscataplasm was prepared with high polymer hydrophilic material as matrix. The determination method of lidocaine was established by HPLC. The in vitro release was studied according to the requirement of Chinese pharmacopoeia (2005) and the percutaneous absorption of compound hyperostosiscataplasm was evaluated in use of the Franz diffusion cell. Results: The release mechanism of compound hyperostosiscataplasm in vitro coincide with zero-order kinetics Equation. The release rate was 3.996mg·cm-2·h-1/2 Lidocaine in cataplasm permeated in vitro at the speed of 0.073mg·cm-2·h-1 by zero-order kinetics. Conclusions: The compound hyperostosiscataplasm is a skeleton controlled TDDS whose permeation speed is limited by skin.