Cellular Fingerprints: A Novel Concept for the Integration of Experimental Data and Compound-Target-Pathway Relations

摘要

The pharmaceutical industry is hunting for high-affinity inhibitors of medical targets, but most of them fail in clinical trials because of severe side effects. On the other hand, there is a growing knowledge about multiple targets and their role in various signalling pathways. Therefore, the integration of experimental data, literature knowledge about drugs, targets, their metabolism, ontology, and related pathways is an important task to achieve better understanding of drug mechanisms on a systems biological level.