Oral and intravenous phenylalanine kinetics in adult mixed hounds

摘要

There are few estimates of single amino acid (AA) kinetics in adult mammals and none in adult dogs. Knowledge of the differences in AA kinetics between healthy adult dogs and those in different physiological stages or disease states could help td elucidate potential improvements to diets recommended for those populations. The objectives of these studies were the following: i) to validate the use of oral (O) isotope studies, ii) to define phenylalanine (PHE) kinetics when the tracer was given intravenously (IV) and orally, and iii) to compare kinetics from IV and O studies to enable an estimate of the effects of gastric emptying and splanchnic metabolism on PHE kinetics in 5 adult, spayed, mixed hound female dogs.