The effects of LED rectal irradiation on the experimental ulcerative colitis in rats

摘要

We evaluated the effects of light emitting diode(LED λ 632.8nm; power 4.0mw)applied directly to the colon on the experimental ulcerative colitis. 34 rats were divided into 3 groups, which was LED treatment group (n=12), model group (n=12), and normal control group (n=10). Given glacial acetic acid (5%) intra-anally so as to be replicated the rat model of ulcerative colitis. LED irradiation was used to curative group, with 30min each time, once per day. The period of treatment was one week. Then the activity of superoxide dismutase (SOD) and content of malondi-aldehyde (MDA) in the blood plasma were detected and the histopathological study in Colonic tissue was performed. The degree of the Colonic tissue injury in curative group was not as significant as that in the model group. Comparing with model group, the Content of MDA in LED curative group was reductive and the activity of SOD was increased significantly. We concluded that the LED irradiation can protect colonic mucosa from acetic acid induced damage in rats and the effects may be related to the photobiomodulation of LED.