Magnetic Properties, Self-Temperature Rising Characteristics, and Biocompatibility of NiFe2O4 Nanoparticles for Hyperthermia Applications

摘要

The interesting of magnetic nanoparticles for biomedical applications such as disease diagnosis using antigen-antibody reaction, drug delivery, hyperthermia, MRI contrast agents, and cell-repairing has been dramatically increased due to their promising physical and biotechnical advantages. In particular, hyperthermia, one of the therapy modalities for cancer treatment, has been considered to be useful for treating localized or deeply-seated tumor cells with temperatures in the range of 41～45°C[1]. The main reason is that this modality is expected to effectively reduce the "side effect", which is severely considered in current cancer therapies. The initiative experimental investigations of the application of magnetic materials for hyperthermia were first carried out by Gilchrist et al in 1957 [2]. However, it has been revealed that magnetic mediated hyperthermia has a lot of technical restrictions for the real clinical applications due to the urgently required physical and clinical properties such as high magnetic moment, high magnetic susceptibility including magnetic permeability, heat conduction and deposition rate, specific absorption rate (SAR), and capabilities of controlling particle size, shape, and size distributions.