Acyclovir-loaded PAN nanofiber membranes prepared using a special electrospinning process

摘要

A special electrospinning process was successfully developed for the preparation of acyclovir-loaded PAN nanofiber membrane in the present study. An additional apparatus for adjusting the temperature of the spinning solutions was fitted on the glass syringe for easy spinning and getting better performance of nanofibers. PAN nanofibers and acyclovir-loaded PAN nanofibers were prepared using this process with DMSO as solvent. The surface topographies of the as-prepared nanofiber membranes were observed using polarization optical microscope. The results demonstrated that the nanofibers were more uniform with very smooth surface when the electrospinning process was carried out at 80°C. However, the nanofibers were conglutinated together to form fiber mats with a poor structure when electrospinning was conducted at a normal ambient temperature. Electrospinning at 80°C was able to form drug-loaded nanofibers with uniform structure and well drug distribution, whereas electrospinning at 60°C resulted in a phase separation due to the poor solubility of acyclovir in DMSO at a lower temperature. Rising electrospinning temperature facilitates the preparation of drug-loaded nanofibers.