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Lateral-Ending Neurorrhaphy: Evaluation of Axonal Growth with and Without Epineurectomy

机译:侧向结尾的神经腐败:评估轴突生长和不含渗漏术的轴突生长

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The injury repairings of the peripheral nerves are still unsatisfactory. The ideal treatment is the neurorrhaphy trying to coapt the stumps in an acute phase. In the great segmentary losses or in the avulsions of roots of the branchial plexus, the neurotizations and the long autologus grafts are used, but they always cause sequelae in the donor's area. The lateral-ending neurorrhaphy is an alternative treatment, therefore it has as objective the reestablishment of the function of the injured nerve, without promoting damage to the donor's area. It would be an excellent strategy, if it were not surrounded by doubts and controversies. In this study, we use 20 male Wistar rats, divided in two groups of 10. We dry up a segment of 1.0 cm of the tibial nerve and the we coapt it in the lateral face of the sciatic D, neurotizing the adjacent musculature. Group 1 without epineural window, group 2 with epineural window. After 4 weeks, the histological study of the grafted segment and the sciatic nerve was carried through. The results had demonstrated absence of statistically significant difference between the two groups. Both contained rare myelinated fibrae. We concluded that the lateral-ending neurorrhaphy, with or without epineural window, does not promote efficient distal remyelinization.
机译:周围神经的损伤修复仍然不令人满意。理想的治疗是试图在急性期内凝练的神经腐败。在良好的分部损失或分支丛的根部,使用神经调节和长自身移植物,但它们总是在捐赠者区域引起后遗症。侧向结束的神经腐败是一种替代治疗,因此它具有目的重建受伤神经的功能,而不促进对捐助者的地区的损害。如果它不被怀疑和争议包围,那将是一个出色的策略。在这项研究中,我们使用20只雄性Wistar大鼠,分为两组10。我们干燥一段1.0厘米的胫骨神经,我们在坐骨的侧面的侧面,神经调节邻近的肌肉组织。第1组没有内蒙古窗口,第2组与内膜内窗口。 4周后,通过接枝段和坐骨神经的组织学研究进行。结果证明两组之间没有统计学上显着的差异。两者都含有罕见的纤维状纤维。我们得出结论,侧向结束的神经腐败,有或没有内膜内窗口,不会促进有效的远端核化。

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