Size of Nanoparticles Affect Intracellular Trafficking in Live Cells

摘要

The delivery of therapeutics in nanoparticles capable of quickly traversing the cytoplasm and entering the nucleus via the nuclear pore complex (NPC) has many potential clinical applications. The effectiveness of chemotherapeutics such as alkylating agents, genetic material such as DNA, and transcription inhibitors may increase significantly if delivered directly to the nucleus.