SAMPLING FOR POINT-OF-CARE ANALYSIS OF LITHIUM IN WHOLE BLOOD WITH CHIP BASED CE

摘要

In this paper the sampling and transfer of blood for microchip capillary electrophoresis (CE) microchip is studied. Following the coupling of microneedle arrays to a CE chip, which has been introduced before [1], the requirements for quantitation of physiological relevant concentrations of inorganic cations are examined in further detail. Additionally a new method is presented using a blood sampler sealed at one end with a filter membrane to conveniently transfer samples to the chip. For the first time we demonstrate rapid and accurate determination of lithium at a clinical relevant concentration of 0.6 mM in blood plasma from a patient under lithium medication.