Secondary structure analysis of polypeptides by a model utilizing excitonic coupling between amide I modes.

摘要

The amide I band in the IR and to a less extent in the Raman spectra of polypeptides and proteins are frequently used to determine their secondary structure composition [1]. The structural sensitivity of the corresponding amide I mode, which is predominantly a CO stretching vibration, is generally attributed to the influence of hydrogen bonding on the force constant of the carbonyl bond.