The Determination and Quantification of Human Pharmaceuticals in Aqueous Environmental Samples

摘要

Analytical methods were developed to determine several basic and acidic pharmaceutical compounds including anti-hypertensives, anti-inflammatories, and anti-depressants, in various surface waters. The methods include solid phase extraction (SPE) that acts as a cleanup and concentrates the sample a thousand-fold. The samples were analyzed by LC/MS/MS using two mass spectrometry techniques, MS/MS to confirm the presence of the pharmaceuticals in the samples and MRM to quantitate. Identification of nine out of ten compounds was found in both the city of Lawrence, KS influent and effluent wastewater samples. Kansas River water showed the presence of seven out of ten compounds and in tap water five out of ten compounds were detected.