Repeated Response to Antithymocyte Globulin in a Case of Aplastic Anemia-Paroxysma! Nocturnal Hemoglobinuria Syndrome

摘要

Summary: We report a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome who was successfully treated with repeated administration of antithymocyte globulin (ATG). The patient became transfusion-independent after a first course of horse ATG, however, became transfusion-dependent again after nine month. The patient received a second course of horse ATG, resulting in the improvement of anemia and thrombocytopenia again. The patient is currently transfusion-independent with mild pancytopenia and PNH. This case clearly shows that repeated treatment with ATG is a good strategy even in the recurrent cases of AA-PNH syndrome.