Paroxysmal Nocturnal Hemoglobinuria in Association with Chronic Myelofibrosis

摘要

Summary: Two cases of chronic idiopathic myelofibrosis (CEVfF) associated with paroxixmal nocturnal hemoglobinuria (PNH) are descrived. Case 1 was 60 yrs old male. He was diagnosed CIMF in 1990. Association of PNH was diagnosed in 1995. PNH clone expand gradually, frequent hemolytic episodes were observed. He died by liver failure in 1999. Case 2 was 51 yrs old male. He was daiagnosed as CIMF in 1993 and association of PNH was diagnosed in 2000. Case 2 has no typical hemolytic episode so far. Since both diseases belong to clonal diorder, it is suggested clonal evolution was occurred in CIMF and developed PNH.