Evaluationg in vitro neutralizing activity of anit-Pertussis antibodies

摘要

In recent years, incidences of pertussis, or whooping cough, increased worldwide, particularly in infants.1 This partly resulted from the introduction of a new acellular vaccine, which loses effectiveness long term, enabling pathogen growth in adults and transfer to infants.2 Although generally mild in adults, pertussis causes hospitalization and/or death in infants too young to be vaccinated. Our lab develops a therapeutic consisting of two anti-pertussis toxin antibodies that help fight the disease by direct injection into sick individuals.