Hydrogen bonding is the most important intermolecular interaction mode in many liquid systems and in almost all biochemical phenomena. Despite of its fundamental importance, our knowledge about hydrogen bonding and the available schemes for the quantification of hydrogen bond enthalpy and entropy are very limited. This surely is due to the complex nature of hydrogen bonding, since it arises from a complicated combination of electrostatics, molecular orbital interactions, dispersion and Pauli repulsion. Hence a fully theoretical description of hydrogen bonding is currently out of reach, at least for most molecules of practical importance.
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