Determination of Design Space for Oral Pharmaceutical Drugs(PPT)

摘要

1. DS determination: multi-response optimization and overlapping responses 2. Multi-response optimization: DS bounds in neighborhood of optimum conditions 3. Overlapping responses: DS bounds from the global lower and upper specification limits 4. Method effectiveness measure: Composite Desirability 5. Best performance: Experimental Design analysis - proposed when the data are complete and there is little uncertainty 6. Bayesian approach: proposed if data involve high uncertainty and correlation structures 7. Bioequivalence introduced in Experimental Design and DS determination as a CQA with f2 values