1. Developed a general workflow for implementation of the metabolite valve concept in E. coli 2. Successfully implemented a system for redirecting flux in upper glycolysis that can be used to control cell physiology and increase myo-inositol yields and titers 3. Ongoing work includes - Integration with full glucaric acid pathway - Development of transcriptional controls for autonomous switching to production mode - Exploration of optimal switching time based on metabolic models
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