CONFORMATION-DEPENDENT SEQUENCE DESIGN OF COPOLYMERS: Example of bio-evolution mimetics approach

摘要

We present recent data from our Monte Carlo computer simulation study of the properties of AB-copolymer globules that depend strongly on the primary sequence of the A and B monomers. Several primary sequences were studied: random, random-block, regular, and designed sequences. By using the spatial conformation of the homopolymer chain we compared three models: protein-like copolymers, AB-copolymers modeling membrane proteins, and ABC-copolymers modeling proteins with an active enzymatic center. We found evidence that an AB-copolymer chain with a primary sequence prepared on the basis of a particular conformation of a homopolymer chain by a coloring procedure preserves memory about its parent spatial conformation. By analyzing the power spectra of AB-sequences, we find long-range power-law correlations for the copolymers with the designed primary sequences.