Circuit simulation of memory field modulation by dopamine Dl receptor activation

摘要

We have developed a computational model of the PFC circuit that incorporates dopamine effects via Dl receptor activation. The computer simulation with this model shows an inverted-U shaped concentration-dependent effect of dopamine on the delay-period activity, which is consistent with the experimental result (Nature 376 (1995) 572). The activities of the pyramidal cells (both the baseline and the signal components) are suppressed in high Dl receptor activation levels. The simulation suggests that this is due to feedforward inhibition when the decrement of the AMPA-type currents is weak enough. When it is stronger, however, recurrent inhibition dominates the inhibition.