Factorial Design Analysis Of Esterification Of n-Butanol With Phosphorous Oxychloride In The Synthesis Of Tri n-Butyl Phosphate (TBP)

摘要

Factorial design analysis was applied to the study of process variables in the esterification stage in the synthesis of TBP. Reaction temperature, mole ratio of reactants (POCl_3:C_4H_9OH), and reaction time were studies in the range of 10°C to 20°C, 1:6 to 1:12 and 2 to 7 hours respectively. ANQVA analysis indicated that the mole ratio, reaction temperature arid reaction time are effective for the yield of TBP in that order, whereas interactional effect between temperature and mole ratio is more prominent than the interactional effects of temperature - reaction time and reaction temperature - mole ratio. A regression equation was calculated from the tests; this permitted the derivation of response surface, which provides yield levels in relation to the levels of the factors adopted in experiments. This visualization helped in setting-up the levels of operating variables for maximizing the yield of TBP.