Susceptibility loci for radiation lymphomagenesis in mice

摘要

BALB/c and STS mice are susceptible and resistant, respectively, to radiation lymphomagenesis. Our previous study suggested that Prkdc encoding DNA-dependent protein kinase (DNA-PKcs) is a candidate for the lymphoma susceptibility locus on chromosome 16. The STS-derived segment with the wild-type Prkdc allele confers resistance in BALB/c, a variant defective in DNA-PKcs. The presence of a lymphoma susceptibility locus on chromosome 4 has also been suggested. To assess the effects of these loci on the susceptibility, we subjected chromosome 16 and chromosome 4 congenic lines by 4x 1.1 and/or 1.7 Gy of X-irradiation. In the chromosome 16 congenic lines carrying the wild-type STS allele at Prkdc, lymphoma resistance was prominent after 4x1.1 Gy of X-irradiation, but modest at 4 x 1.7 Gy. Mice with the proximal half of STS-derived chromosome 4 showed resistance to the induction of lymphomas by the 4 x 1,7 Gy X-irradiation procedure. Thus, lymphoma susceptibility is controlled by more than one gene with differenteffects.