Fluorescent pH-/Thermo-responsive Micelles from Block Copolymers Synthesized via Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization

摘要

RAFT polymerization permits the synthesis of complex polymeric architectures1-6 in an easy and versatile process.7-8 It allows the synthesis of a wide range of functional controlled-structure copolymers showing a block that can respond to alteration of its environment. We have synthesized diblock copolymers of N-isopropylacrylamide (NIPAAM),a fluorescent tag,based on N-vinylcarbazole (NVC) and 2- (dimethylamino)ethyl acrylate (DMAEA) via RAFT polymerization. PNIPAAM undergoes a coil-globular transition at temperature above the lower critical solution temperature (LCST) and is thus tunable to be hydrophilic or hydrophobic9 whereas PDMAEA remains hydrophilic at all temperature but can be reversibly changed depending on pH. This work focuses on the design and applications of (PNIPAAM-co-PNVC)- b-PDMAEA as building block for responsive nanostructures.