Biocompatibility and Drug Release Properties of Electrospun Halloysite Nanotube-Doped Poly(lactic-co-glycolic acid) Composite Nanofibers

摘要

Electrospinning has been used as a common technology to fabricate tissue engineering scaffolds. Organic/inorganic hybrid nanofiber systems have generated great interest in the area of tissue engineering and drug delivery. In this study, we are aiming to develop electrospun nanofiber-based scaffolding materials for both tissue engineering and pharmaceutical sciences. Traditional polymer nanofibers lack enough mechanical strength and often have a burst release profile when drug molecules are incorporated within the nanofibers. In this study, we incorporated halloysite nanotubes (HNTs) within poly(lactic-co-glycolic acid) (PLGA) nanofibers in order to improve the mechanical properties of the fibers, and to develop a double-container (both HNT and PLGA are containers ) drug delivery system, avoiding the burst release of the incorporated drugs.