Self-Assembly and Dynamics of Peptide- Functionalized Polyphenylene Dendrimers

摘要

Dendrimer chemistry is considered a pioneering tool for applications in drug delivery since it offers ideal dimensions, monodispersity, solubility, biocompatibility, unique spherical shape that, in addition, is highly functionalizable. Recent progress in this direction has been the development of synthetic routes leading to peptide- functionalization of polyphenylene dendrimers. These molecules are monodisperse and shape-persistent, with topologically isolated, non- interacting functional groups that are employed as scaffolds for the attachment of poly-L-lysines giving rise to core-shell nanostructured materials. In addition, polyphenylene dendrimers bearing the fluorescent perylenediimide core provide the possibility of optical detection of the dendritic conjugates.