Self-assembled Stereocomplexes Formed from Mikto-arm PEG-b-PLA for Controlled Delivery of Anticancer Drug

摘要

Progress in controlled or living polymerization techniques combined with new synthetic methodologies and efficient organic reactions have had an enormous impact on the ease and level of control on polymer design for functional materials and complex architectures.[1-3] These structures provided solutions to a number of technical challenges including drug delivery,and self-assembly. Paclitaxel,one of the best antineoplastic drugs,found from nature has excellent therapeutic effects against a wide spectrum of cancers including ovarian,breast and colon cancer [4-6]. However,it has limited solubility in water (0.3 mg/L at 37癈),making application of paclitaxel in cancer therapy difficult. Thus,various polymer-based carriers have been explored with a growing need to develop an alternative and efficient delivery system. Among them,biodegradable nanosized micelles are more advantageous than other carriers due to their ability of achieving passive targeting to leaky tumor tissues,and their well-defined core/shell structure having a hydrophilic shell for avoiding uptake of the reticuloendothelial system (RES),which prolongs blood circulation of the drug.