Self-assembled gel for controlled delivery of biologics and unstable drugs

摘要

Gels are formed in self-assembly processes with limited heating or without heating, based on low-molecular weight amphiphilic molecules that are generally regarded as safe (GRAS). The selective range ratio between the organic solvent and water, or the aqueous solution in the medium causes the GRAS low molecular weight amphiphile to form a uniform self-supporting gel encapsulation drug delivered under very mild conditions Make it possible. Enzymes, antibodies, and proteins, including serum albumin, are loaded into self-assembled gels to provide sustained and / or responsive delivery. The encapsulated proteins retain at least 70%, 80% or 90% of their activity under various storage conditions for several days.