Shape Effects of Nanoparticles Conjugated with Cell-Penetrating Peptide (HIV Tat PTD) on CHO Cell Uptake

摘要

The ability of nanoparticles to enter cells will bring about significant expansion of their use in nanomedicine. Thus far, attention has been focused largely on spherical nanoparticles as agents for imaging and drug or gene delivery. Interesting results that were recently reported from the Discher laboratory indicate that cylindrical polymer assemblies have great promise for in vivo applications. However, the effects of the shape of the nanoparticles on the rate and amount of cellular uptake have not yet been extensively investigated. As reported herein, we have compared polymeric nanoparticles of different shapes as well as different amounts of cell penetration peptide conjugated onto these nanoparticles for their capabilities for cell entrance.