Potential Nutritional Interventions to Reduce Physical- and/or Hyperthermia-Induced Gut Barrier Dysfxinction

摘要

The gastrointestinal (GI) barrier or 'gut barrier' consists of the epithelia (i.e., enterocyte membranes and tight junctions between them) along with secreted mucus and resident tissue macrophages. Working together, these factors restrict many harmful substances from entering the body's internal environment. Such substances include food antigens, bile, hydrolytic enzymes, bacteria, and bacterial components such,as endotoxin (i.e., lipopolysaccharide, LPS). Dysfunction of the GI barrier (i.e.,loss of gut barrier integrity) can cause increased diffusion of large normally restricted, molecules from the gut lumen into the internal environment (i.e., increased GI permeability). While a certain low level of permeability can always be measured,this is normally kept from causing harm by the immune system.