EMERGENCE OF HIGHLY MULTIDRUG-RESISTANT SALMONELLA NEWPORT (NEWPORT MDR-AMPC) INFECTIONS

摘要

Highly multidrug-resistant Salmonella Newport emerged in 1999 and has spread to many parts of the United States. These isolates are characterized by decreased susceptibility or resistance to most beta-lactam antimicrobial agents including: amoxicillin/clavulanate, a penicillin-inhibitor combination; cefoxitin, a cephamycin; and ceftriaxone, a third generation cephalosporin. Resistance to these beta-lactams is attributable to a plasmid-me-diated AmpC-type enzyme produced by a CMY-2 gene. This resistance plasmid is of special concern because of the importance of ceftriaxone in human medicine. We refer to these isolates as Newport MDR-AmpC.