Numerical Analysis of Microvascular Constriction Flow including Red Blood Cells and Liposome-Encapsulated Hemoglobin

摘要

Lattice Boltzmann analysis of the microvascular constriction flow after the partial replacement of red blood cell (RBC) with liposome-encapsulated hemoglobin (LEH) was performed with the aim of predicting the effect of LEH on primary pulmonary hypertension (PPH). Two models were considered - a normal model and a PPH model. In the case of only RBC flow, we revealed the relation between the constriction width in the PPH model and the vascular resistance. On the other hand, after RBC-LEH replacement, for both of the normal model and the PPH model, the oxygen carrying capacity of RBC does not change significantly by RBC-LEH replacement. Furthermore, the vascular resistance decreased and the total oxygen carrying capacity increased on RBC-LEH replacement.