A Novel Mechanism for the Inhibition of Nitric Oxide Synthase by Amino Acid and Amino Alcohol C_(60) Derivatives

摘要

In recent years we have identified water-soluble fullerene derivatives as an exotic class of NOS inhibitors.Studying a diverse group of fullerene derivatives we have accumulated significant data that suggests that there is a very interesting and sensitive structure-function relationship that affects their potency,isoform selectivity and even the pharmacologic mechanism of action.This suggests a molecular specific interaction of fullerenes with the enzyme.