Electrochemical Quartz Crystal Microbalance Study of Protein Adsorption on the Poly(pyrrole)-Biotin Modified Electrodes

摘要

In a human body,albumin is responsible,among others,for isolation of any foreign intruding solid object.Thus,implants can be clogged and rejected.Therefore,we have undertaken an effort to find conditions,in vitro,under which adsorption of albumin is a solid substrate surface is prevented.Virtually,albumin does not interact with avidin.Therefore,an idea was explored to coat,first,the studied solid surface with avidin in hope that albumin will not adsorb onto it afterwards.For effective adsorption of avidin,we used an avidin-biotin immobilization technology.